Prolonged FGF signaling is necessary for lung and liver induction in Xenopus.

ABSTRACT:

Background

FGF signaling plays numerous roles during organogenesis of the embryonic gut tube. Mouse explant studies suggest that different thresholds of FGF signaling from the cardiogenic mesoderm induce lung, liver, and pancreas lineages from the ventral foregut progenitor cells. The mechanisms that regulate FGF dose in vivo are unknown. Here we use Xenopus embryos to examine the hypothesis that a prolonged duration of FGF signaling from the mesoderm is required to induce foregut organs.

Results

We show that both mesoderm and FGF signaling are required for liver and lung development in Xenopus; formally demonstrating that this important step in organ induction is conserved with other vertebrate species. Prolonged contact with the mesoderm and persistent FGF signaling throug

SUBMITTER: Shifley ET 

PROVIDER: S-EPMC3514138 | biostudies-literature | 2012 Sep

REPOSITORIES: biostudies-literature