Nonsteroidal anti-inflammatory drug use, chronic liver disease, and hepatocellular carcinoma.

ABSTRACT:

Background

Nonsteroidal anti-inflammatory drugs (NSAIDs) have been shown to reduce chronic inflammation and risk of many cancers, but their effect on risk of hepatocellular carcinoma (HCC) and death due to chronic liver disease (CLD) has not been investigated.

Methods

We analyzed prospective data on 300504 men and women aged 50 to 71 years in the National Institutes of Health-AARP Diet and Health Study cohort and linked self-reported aspirin and nonaspirin NSAID use with registry-confirmed diagnoses of HCC (n=250) and death due to CLD (n=428, excluding HCC). We calculated hazard rate ratios (RRs) and their two-sided 95% confidence intervals (CIs) using Cox proportional hazard regression models with adjustment for age, sex, race/ethnicity, cigarette smoking, alcohol consumpti

SUBMITTER: Sahasrabuddhe VV 

PROVIDER: S-EPMC3514167 | biostudies-literature | 2012 Dec

REPOSITORIES: biostudies-literature