Neurological and developmental outcome in extremely preterm children born in England in 1995 and 2006: the EPICure studies.

ABSTRACT:

Objective

To determine outcomes at age 3 years in babies born before 27 completed weeks' gestation in 2006, and to evaluate changes in outcome since 1995 for babies born between 22 and 25 weeks' gestation.

Design

Prospective national cohort studies, EPICure and EPICure 2.

Setting

Hospital and home based evaluations, England.

Participants

1031 surviving babies born in 2006 before 27 completed weeks' gestation. Outcomes for 584 babies born at 22-25 weeks' gestation were compared with those of 260 surviving babies of the same gestational age born in 1995.

Main outcome measures

Survival to age 3 years, impairment (2008 consensus definitions), and developmental scores. Multiple imputation was used to account for the high proportion of missing data in the 2006

SUBMITTER: Moore T 

PROVIDER: S-EPMC3514471 | biostudies-literature | 2012 Dec

REPOSITORIES: biostudies-literature