Corneal epithelial thickness mapping by Fourier-domain optical coherence tomography in normal and keratoconic eyes.

ABSTRACT:

Objective

To map the corneal epithelial thickness with Fourier-domain optical coherence tomography (OCT) and to develop epithelial thickness-based variables for keratoconus detection.

Design

Cross-sectional observational study.

Participants

One hundred forty-five eyes from 76 normal subjects and 35 keratoconic eyes from 22 patients.

Methods

A 26,000-Hz Fourier-domain OCT system with 5-μm axial resolution was used. The cornea was imaged with a Pachymetry + Cpwr scan pattern (6-mm scan diameter, 8 radials, 1024 axial-scans each, repeated 5 times) centered on the pupil. Three scans were obtained at a single visit in a prospective study. A computer algorithm was developed to map the corneal epithelial thickness automatically. Zonal epithelial thicknesses and 5 diag

SUBMITTER: Li Y 

PROVIDER: S-EPMC3514625 | biostudies-literature | 2012 Dec

REPOSITORIES: biostudies-literature