Electrochemotherapy: technological advancements for efficient electroporation-based treatment of internal tumors.

ABSTRACT: Electrochemotherapy, a combination of high voltage electric pulses and of an anticancer drug, has been demonstrated to be highly effective in treatment of cutaneous and subcutaneous tumors. Unique properties of electrochemotherapy (e.g., high specificity for targeting cancer cells, high degree of localization of treatment effect, capacity for preserving the innate immune response and the structure of the extracellular matrix) are facilitating its wide spread in the clinics. Due to high effectiveness of electrochemotherapy in treatment of cutaneous and subcutaneous tumors regardless of histological origin, there are now attempts to extend its use to treatment of internal tumors. To advance the applicability of electrochemotherapy to treatment of internal solid tumors, new technological deve

SUBMITTER: Miklavcic D 

PROVIDER: S-EPMC3514699 | biostudies-literature | 2012 Dec

REPOSITORIES: biostudies-literature