Microsatellites grant more stable flanking genes.

ABSTRACT:

Background

Microsatellites, or simple sequence repeats (SSRs), are DNA sequences that include tandem copies of specific sequences no longer than six bases. SSRs are ubiquitous in all genomes and highly mutable.

Presentation of the hypothesis

Results from previous studies suggest that flanking regions of SSR are exhibit high stability in a wide range of organisms. We hypothesized that the SSRs ability to discard weak DNA polymerases could be responsible for this unusual stability. . When the weak polymerases are being decayed over SSRs, the flanking sequences would have higher opportunity to be replicated by more stable DNA polymerases. We present evidence of the molecular basis of our hypothesis.

Testing the hypothesis

The hypothesis could be tested by examining the a

SUBMITTER: Joukhadar R 

PROVIDER: S-EPMC3515467 | biostudies-literature | 2012 Oct

REPOSITORIES: biostudies-literature