The metabolomic profile of umbilical cord blood in neonatal hypoxic ischaemic encephalopathy.

ABSTRACT:

Background

Hypoxic ischaemic encephalopathy (HIE) in newborns can cause significant long-term neurological disability. The insult is a complex injury characterised by energy failure and disruption of cellular homeostasis, leading to mitochondrial damage. The importance of individual metabolic pathways, and their interaction in the disease process is not fully understood. The aim of this study was to describe and quantify the metabolomic profile of umbilical cord blood samples in a carefully defined population of full-term infants with HIE.

Methods and findings

The injury severity was defined using both the modified Sarnat score and continuous multichannel electroencephalogram. Using these classification systems, our population was divided into those with confirmed HIE (n = 3

SUBMITTER: Walsh BH 

PROVIDER: S-EPMC3515614 | biostudies-literature | 2012

REPOSITORIES: biostudies-literature