The influence of five monoamine genes on trajectories of depressive symptoms across adolescence and young adulthood.

ABSTRACT: The influence of five monoamine candidate genes on depressive symptom trajectories in adolescence and young adulthood were examined in the Add Health genetic sample. Results indicated that, for all respondents, carriers of the dopamine receptor D4 5-repeat allele were characterized by distinct depressive symptom trajectories across adolescence and early adulthood. Similarly, for males, individuals with the monoamine oxidase A 3.5-repeat allele exhibited unique depressive symptom trajectories. Specifically, the trajectories of those with the dopamine receptor D4 5-repeat allele were characterized by rising levels in the transition to adulthood, while their peers were experiencing a normative drop in depressive symptom frequency. Conversely, males with the monoamine oxidase A 3.5-repeat alle

SUBMITTER: Adkins DE 

PROVIDER: S-EPMC3515661 | biostudies-literature | 2012 Feb

REPOSITORIES: biostudies-literature