An integrated in silico approach to design specific inhibitors targeting human poly(a)-specific ribonuclease.

ABSTRACT: Poly(A)-specific ribonuclease (PARN) is an exoribonuclease/deadenylase that degrades 3'-end poly(A) tails in almost all eukaryotic organisms. Much of the biochemical and structural information on PARN comes from the human enzyme. However, the existence of PARN all along the eukaryotic evolutionary ladder requires further and thorough investigation. Although the complete structure of the full-length human PARN, as well as several aspects of the catalytic mechanism still remain elusive, many previous studies indicate that PARN can be used as potent and promising anti-cancer target. In the present study, we attempt to complement the existing structural information on PARN with in-depth bioinformatics analyses, in order to get a hologram of the molecular evolution of PARNs active site. In an e

SUBMITTER: Vlachakis D 

PROVIDER: S-EPMC3516499 | biostudies-literature | 2012

REPOSITORIES: biostudies-literature