Suppression of activin A signals inhibits growth of malignant pleural mesothelioma cells.

ABSTRACT:

Background

Activins control the growth of several tumour types including thoracic malignancies. In the present study, we investigated their expression and function in malignant pleural mesothelioma (MPM).

Methods

The expression of activins and activin receptors was analysed by quantitative PCR in a panel of MPM cell lines. Activin A expression was further analysed by immunohistochemistry in MPM tissue specimens (N=53). Subsequently, MPM cells were treated with activin A, activin receptor inhibitors or activin-targeting siRNA and the impact on cell viability, proliferation, migration and signalling was assessed.

Results

Concomitant expression of activin subunits and receptors was found in all cell lines, and activin A was overexpressed in most cell lines compared with

SUBMITTER: Hoda MA 

PROVIDER: S-EPMC3516694 | biostudies-literature | 2012 Dec

REPOSITORIES: biostudies-literature