Identification of circulating microRNAs as diagnostic biomarkers for use in multiple myeloma.

ABSTRACT:

Background

Multiple myeloma is a plasma cell disorder that is characterised by clonal proliferation of malignant plasma cells in the bone marrow, monoclonal paraprotein in the blood or urine and associated organ dysfunction. It accounts for approximately 1% of cancers and 13% of haematological cancers. Myeloma arises from an asymptomatic proliferation of monoclonal plasma cells termed monoclonal gammopathy of undetermined significance (MGUS).

Methods

MicroRNA expression profiling of serum samples was performed on three patient groups as well as normal controls. Validation of the nine microRNAs detected as promising biomarkers was carried out using TaqMan quantitative reverse transcription PCR. MicroRNA levels in serum were normalised using standard curves to determine the nu

SUBMITTER: Jones CI 

PROVIDER: S-EPMC3516695 | biostudies-literature | 2012 Dec

REPOSITORIES: biostudies-literature