Ontology highlight
ABSTRACT:
SUBMITTER: Wu X
PROVIDER: S-EPMC3516815 | biostudies-literature | 2011 Sep
REPOSITORIES: biostudies-literature
Science (New York, N.Y.) 20110811 6049
Antibody VRC01 is a human immunoglobulin that neutralizes about 90% of HIV-1 isolates. To understand how such broadly neutralizing antibodies develop, we used x-ray crystallography and 454 pyrosequencing to characterize additional VRC01-like antibodies from HIV-1-infected individuals. Crystal structures revealed a convergent mode of binding for diverse antibodies to the same CD4-binding-site epitope. A functional genomics analysis of expressed heavy and light chains revealed common pathways of a ...[more]