Ontology highlight
ABSTRACT:
SUBMITTER: Kemp KL
PROVIDER: S-EPMC3517127 | biostudies-literature | 2010 Nov
REPOSITORIES: biostudies-literature
Kemp Kyeorda L KL Levin Steven D SD Stein Paul L PL
European journal of immunology 20101027 11
The Src family kinase Lck is thought to facilitate Th2 differentiation; however, its role in Th1 cells has not been well explored. Using mice that lack Lck in mature T cells, we find that lck(-/-) Th1 skewed cells have normal expression of T-bet and produce IFN-γ at WT levels. However, there is a 3-fold increase in IL-10 producing cells in the mutant cultures. These cells do not have elevated levels of IL-4, GATA3, IL-17 or Foxp3, indicating that they are not Th2, Th17, or Foxp3(+) T regulatory ...[more]