Multicomponent assembly of highly substituted indoles by dual palladium-catalyzed coupling reactions.

ABSTRACT: Highly substituted indoles were synthesized by a palladium-catalyzed reaction involving three independent components in a one-pot reaction. Two distinct palladium-catalyzed coupling reactions occur with a single catalytic system: a Buchwald-Hartwig reaction and an arene-alkene coupling. Quantum chemical computations provide insight into the mechanism of the latter coupling step.

SUBMITTER: Knapp JM 

PROVIDER: S-EPMC3517165 | biostudies-literature | 2012 Oct

REPOSITORIES: biostudies-literature