Multivitamins in the prevention of cancer in men: the Physicians' Health Study II randomized controlled trial.

ABSTRACT:

Context

Multivitamin preparations are the most common dietary supplement, taken by at least one-third of all US adults. Observational studies have not provided evidence regarding associations of multivitamin use with total and site-specific cancer incidence or mortality.

Objective

To determine whether long-term multivitamin supplementation decreases the risk of total and site-specific cancer events among men.

Design, setting, and participants

A large-scale, randomized, double-blind, placebo controlled trial (Physicians" Health Study II) of 14 641 male US physicians initially aged 50 years or older (mean [SD] age, 64.3 [9.2] years), including 1312 men with a history of cancer at randomization, enrolled in a common multivitamin study that began in 1997 with treatment an

SUBMITTER: Gaziano JM 

PROVIDER: S-EPMC3517179 | biostudies-literature | 2012 Nov

REPOSITORIES: biostudies-literature