Identification and characterization of human leukocyte antigen class I ligands in renal cell carcinoma cells.

ABSTRACT: The presentation of tumor antigen-derived peptides by human leukocyte antigen (HLA) class I surface antigens on tumor cells is a key prerequisite to trigger effective T-cell responses in cancer patients. Multiple complementary strategies like cDNA and serological expression cloning, reverse immunology and different 'ome'-based methods have been employed to identify potential T-cell targets. This report focuses on a ligandomic profiling approach leading to the identification of 49 naturally processed HLA class I peptide ligands presented on the cell surface of renal cell carcinoma (RCC) cells. The source proteins of the defined HLA ligands are classified according to their biological function and subcellular localization. Previously established cDNA microarray data of paired tissue specimen

SUBMITTER: Seliger B 

PROVIDER: S-EPMC3517181 | biostudies-literature | 2011 Jun

REPOSITORIES: biostudies-literature