Gp100 peptide vaccine and interleukin-2 in patients with advanced melanoma.

ABSTRACT:

Background

Stimulating an immune response against cancer with the use of vaccines remains a challenge. We hypothesized that combining a melanoma vaccine with interleukin-2, an immune activating agent, could improve outcomes. In a previous phase 2 study, patients with metastatic melanoma receiving high-dose interleukin-2 plus the gp100:209-217(210M) peptide vaccine had a higher rate of response than the rate that is expected among patients who are treated with interleukin-2 alone.

Methods

We conducted a randomized, phase 3 trial involving 185 patients at 21 centers. Eligibility criteria included stage IV or locally advanced stage III cutaneous melanoma, expression of HLA*A0201, an absence of brain metastases, and suitability for high-dose interleukin-2 therapy. Patients were

SUBMITTER: Schwartzentruber DJ 

PROVIDER: S-EPMC3517182 | biostudies-literature | 2011 Jun

REPOSITORIES: biostudies-literature