Salinomycin, a polyether ionophoric antibiotic, inhibits adipogenesis.

ABSTRACT: The polyether ionophoric antibiotics including monensin, salinomycin, and narasin, are widely used in veterinary medicine and as food additives and growth promoters in animal husbandry including poultry farming. Their effects on human health, however, are not fully understood. Recent studies showed that salinomycin is a cancer stem cell inhibitor. Since poultry consumption has risen sharply in the last three decades, we asked whether the consumption of meat tainted with growth promoting antibiotics might have effects on adipose cells. We showed in this report that the ionophoric antibiotics inhibit the differentiation of preadipocytes into adipocytes. The block of differentiation is not due to the induction of apoptosis nor the inhibition of cell proliferation. In addition, salinomycin als

SUBMITTER: Szkudlarek-Mikho M 

PROVIDER: S-EPMC3517190 | biostudies-literature | 2012 Nov

REPOSITORIES: biostudies-literature