Boosting immune response with the invariant chain segments via association with non-peptide binding region of major histocompatibility complex class II molecules.

ABSTRACT:

Background

Based on binding of invariant chain (Ii) to major histocompatibility complex (MHC) class II molecules to form complexes, Ii-segment hybrids, Ii-key structure linking an epitope, or Ii class II-associated invariant chain peptide (CLIP) replaced with an epitope were used to increase immune response. It is currently unknown whether the Ii-segment cytosolic and transmembrane domains bind to the MHC non-peptide binding region (PBR) and consequently influence immune response. To investigate the potential role of Ii-segments in the immune response via MHC II/peptide complexes, a few hybrids containing Ii-segments and a multiepitope (F306) from Newcastle disease virus fusion protein (F) were constructed, and their binding effects on MHC II molecules and specific antibody product

SUBMITTER: Chen F 

PROVIDER: S-EPMC3517428 | biostudies-literature | 2012 Sep

REPOSITORIES: biostudies-literature