Cell type-specific termination of transcription by transposable element sequences.

ABSTRACT:

Unlabelled

Background

Transposable elements (TEs) encode sequences necessary for their own transposition, including signals required for the termination of transcription. TE sequences within the introns of human genes show an antisense orientation bias, which has been proposed to reflect selection against TE sequences in the sense orientation owing to their ability to terminate the transcription of host gene transcripts. While there is evidence in support of this model for some elements, the extent to which TE sequences actually terminate transcription of human gene across the genome remains an open question.

Results

Using high-throughput sequencing data, we have characterized over 9,000 distinct TE-derived sequences that provide transcription termination sites for 5

SUBMITTER: Conley AB 

PROVIDER: S-EPMC3517506 | biostudies-literature | 2012 Sep

REPOSITORIES: biostudies-literature