Identification of IL6R and chromosome 11q13.5 as risk loci for asthma.

ABSTRACT:

Background

We aimed to identify novel genetic variants affecting asthma risk, since these might provide novel insights into molecular mechanisms underlying the disease.

Methods

We did a genome-wide association study (GWAS) in 2669 physician-diagnosed asthmatics and 4528 controls from Australia. Seven loci were prioritised for replication after combining our results with those from the GABRIEL consortium (n=26,475), and these were tested in an additional 25,358 independent samples from four in-silico cohorts. Quantitative multi-marker scores of genetic load were constructed on the basis of results from the GABRIEL study and tested for association with asthma in our Australian GWAS dataset.

Findings

Two loci were confirmed to associate with asthma risk in the replicatio

SUBMITTER: Ferreira MA 

PROVIDER: S-EPMC3517659 | biostudies-literature | 2011 Sep

REPOSITORIES: biostudies-literature