Evidence for an interaction of neuronostatin with the orphan G protein-coupled receptor, GPR107.

ABSTRACT: Neuronostatin, derived from the somatostatin preprohormone, is a recently described peptide that is produced by several tissues involved in cardiovascular regulation and metabolism, including the hypothalamus. Injection of neuronostatin into the lateral cerebroventricle led to a dose-related increase in mean arterial pressure (MAP) in rats. Any attempt to inhibit the production of neuronostatin would alter somatostatin production as well, making determination of the physiological relevance of the peptide's pharmacologic effects by compromise of production approaches impossible. Therefore, we employed an alternative approach to identify and compromise the production of the neuronostatin receptor. Because neuronostatin was shown to signal via a PKA-dependent mechanism, we hypothesized that

SUBMITTER: Yosten GL 

PROVIDER: S-EPMC3517703 | biostudies-literature | 2012 Nov

REPOSITORIES: biostudies-literature