Flexible survival strategies of Pseudomonas aeruginosa in biofilms result in increased fitness compared with Candida albicans.

ABSTRACT: The majority of microorganisms persist in nature as surface-attached communities often surrounded by an extracellular matrix, called biofilms. Most natural biofilms are not formed by a single species but by multiple species. Microorganisms not only cooperate as in some multispecies biofilms but also compete for available nutrients. The Gram-negative bacterium Pseudomonas aeruginosa and the polymorphic fungus Candida albicans are two opportunistic pathogens that are often found coexisting in a human host. Several models of mixed biofilms have been reported for these organisms showing antagonistic behavior. To investigate the interaction of P. aeruginosa and C. albicans in more detail, we analyzed the secretome of single and mixed biofilms of both organisms using MALDI-TOF MS/MS at several t

SUBMITTER: Purschke FG 

PROVIDER: S-EPMC3518115 | biostudies-literature | 2012 Dec

REPOSITORIES: biostudies-literature