Oligo- and polymetastatic progression in lung metastasis(es) patients is associated with specific microRNAs.

ABSTRACT:

Rationale

Strategies to stage and treat cancer rely on a presumption of either localized or widespread metastatic disease. An intermediate state of metastasis termed oligometastasis(es) characterized by limited progression has been proposed. Oligometastases are amenable to treatment by surgical resection or radiotherapy.

Methods

We analyzed microRNA expression patterns from lung metastasis samples of patients with ≤ 5 initial metastases resected with curative intent.

Results

Patients were stratified into subgroups based on their rate of metastatic progression. We prioritized microRNAs between patients with the highest and lowest rates of recurrence. We designated these as high rate of progression (HRP) and low rate of progression (LRP); the latter group included patie

SUBMITTER: Lussier YA 

PROVIDER: S-EPMC3518475 | biostudies-literature | 2012

REPOSITORIES: biostudies-literature