Comparative interaction networks: bridging genotype to phenotype.

ABSTRACT: Over the past decade, biomedical research has witnessed an exponential increase in the throughput of the characterization of biological systems. Here we review the recent progress in large-scale methods to determine protein-protein, genetic and chemical-genetic interaction networks. We discuss some of the limitations and advantages of the different methods and give examples of how these networks are being used to study the evolutionary process. Comparative studies have revealed that different types of protein-protein interactions diverge at different rates with high conservation of co-complex membership but rapid divergence of more promiscuous interactions like those that mediate post-translational modifications. These evolutionary trends have consistent genetic consequences with highly co

SUBMITTER: Beltrao P 

PROVIDER: S-EPMC3518490 | biostudies-literature | 2012

REPOSITORIES: biostudies-literature