Metabolic profiling, a noninvasive approach for the detection of experimental colorectal neoplasia.

ABSTRACT: Colorectal cancer is the second leading cause of cancer-related deaths in the United States. Although noninvasive stool-based screening tests are used for the early detection of colorectal neoplasia, concerns have been raised about their sensitivity and specificity. A metabolomics-based approach provides a potential noninvasive strategy to identify biomarkers of colorectal carcinogenesis including premalignant adenomas. Our primary objective was to determine whether a distinct metabolic profile could be found in both feces and plasma during experimental colorectal carcinogenesis. Feces, plasma as well as tumor tissue and normal colorectal mucosa were obtained from A/J mice at several time points following administration of azoxymethane or saline. Ultra-performance liquid chromatography tan

SUBMITTER: Montrose DC 

PROVIDER: S-EPMC3518611 | biostudies-literature | 2012 Dec

REPOSITORIES: biostudies-literature