Takeout-dependent longevity is associated with altered Juvenile Hormone signaling.

ABSTRACT: In order to understand the molecular mechanisms of longevity regulation, we recently performed a screen designed to enrich for genes common to several longevity interventions. Using this approach, we identified the Drosophila melanogaster gene takeout. takeout is upregulated in a variety of long-lived flies, and extends life span when overexpressed. Here, we investigate the mechanisms of takeout-dependent longevity. takeout overexpression specifically in the fat body is sufficient to increase fly longevity and is additive to the longevity effects of Dietary Restriction. takeout long-lived flies do not show phenotypes often associated with increased longevity, such as enhanced stress resistance or major metabolic abnormalities. However, males exhibit greatly diminished courtship behavior, l

SUBMITTER: Chamseddin KH 

PROVIDER: S-EPMC3518612 | biostudies-literature | 2012 Nov-Dec

REPOSITORIES: biostudies-literature