Common obesity-related genetic variants and papillary thyroid cancer risk.

ABSTRACT:

Background

Epidemiologic studies have shown consistent associations between obesity and increased thyroid cancer risk, but, to date, no studies have investigated the relationship between thyroid cancer risk and obesity-related single-nucleotide polymorphisms (SNP).

Methods

We evaluated 575 tag SNPs in 23 obesity-related gene regions in a case-control study of 341 incident papillary thyroid cancer (PTC) cases and 444 controls of European ancestry. Logistic regression models, adjusted for attained age, year of birth, and sex were used to calculate ORs and 95% confidence intervals (CI) with SNP genotypes, coded as 0, 1, and 2 and modeled continuously to calculate P(trend).

Results

Nine of 10 top-ranking SNPs (P(trend) < 0.01) were located in the FTO (fat mass and obesity

SUBMITTER: Kitahara CM 

PROVIDER: S-EPMC3518668 | biostudies-literature | 2012 Dec

REPOSITORIES: biostudies-literature