CREB-binding protein levels in the rat hippocampus fail to predict chronological or cognitive aging.

ABSTRACT: Normal cognitive aging is associated with deficits in memory processes dependent on the hippocampus, along with large-scale changes in the hippocampal expression of many genes. Histone acetylation can broadly influence gene expression and has been recently linked to learning and memory. We hypothesized that CREB-binding protein (CBP), a key histone acetyltransferase, may contribute to memory decline in normal aging. Here, we quantified CBP protein levels in the hippocampus of young, aged unimpaired, and aged impaired rats, classified on the basis of spatial memory capacity documented in the Morris water maze. First, CBP-immunofluorescence was quantified across the principal cell layers of the hippocampus using both low and high resolution laser scanning imaging approaches. Second, digital

SUBMITTER: Tomas Pereira I 

PROVIDER: S-EPMC3518677 | biostudies-literature | 2013 Mar

REPOSITORIES: biostudies-literature