Variation in genes related to obesity, weight, and weight change and risk of contralateral breast cancer in the WECARE Study population.

ABSTRACT:

Background

Body mass index (BMI), a known breast cancer risk factor, could influence breast risk through mechanistic pathways related to sex hormones, insulin resistance, chronic inflammation, and altered levels of adipose-derived hormones. Results from studies of the relationship between BMI and second primary breast cancer have been mixed. To explore the relationship between BMI and asynchronous contralateral breast cancer (CBC), we examined whether variants in genes related to obesity, weight, and weight change are associated with CBC risk.

Methods

Variants in 20 genes [182 single-nucleotide polymorphisms (SNP)] involved in adipose tissue metabolism, energy balance, insulin resistance, and inflammation, as well as those identified through genome-wide association studies (

SUBMITTER: Brooks JD 

PROVIDER: S-EPMC3518741 | biostudies-literature | 2012 Dec

REPOSITORIES: biostudies-literature