Protein modularity, cooperative binding, and hybrid regulatory states underlie transcriptional network diversification.

ABSTRACT: We examine how different transcriptional network structures can evolve from an ancestral network. By characterizing how the ancestral mode of gene regulation for genes specific to a-type cells in yeast species evolved from an activating paradigm to a repressing one, we show that regulatory protein modularity, conversion of one cis-regulatory sequence to another, distribution of binding energy among protein-protein and protein-DNA interactions, and exploitation of ancestral network features all contribute to the evolution of a novel regulatory mode. The formation of this derived mode of regulation did not disrupt the ancestral mode and thereby created a hybrid regulatory state where both means of transcription regulation (ancestral and derived) contribute to the conserved expression pattern

SUBMITTER: Baker CR 

PROVIDER: S-EPMC3519278 | biostudies-literature | 2012 Sep

REPOSITORIES: biostudies-literature