Chiral Indoline Synthesis Via Enantioselective Intramolecular Copper-Catalyzed Alkene Hydroamination.

ABSTRACT: An enantioselective copper-catalyzed hydroamination / cyclization of N-sulfonyl-2-allylanilines for the synthesis of chiral 2-methylindolines is reported. Chiral 2-methylindolines are important subunits in drugs and bioactive compounds. This method provides chiral N-sulfonyl-2-methyl indolines in up to 90% ee.

SUBMITTER: Turnpenny BW 

PROVIDER: S-EPMC3519432 | biostudies-literature | 2012 Nov

REPOSITORIES: biostudies-literature