Cell type-specific properties of subicular GABAergic currents shape hippocampal output firing mode.

ABSTRACT: GABAergic function of the subiculum is central to the regulation of hippocampal output activity. Subicular neuronal networks are indeed under potent control by local inhibition. However, information about the properties of GABAergic currents generated by neurons of this parahippocampal area in normal tissue is still missing. Here, we describe GABA(A) receptor (GABA(A)R)-mediated phasic and tonic currents generated by principal cells (PCs) and interneurons (INs) of the rat subiculum. We show that in spite of similar synaptic current densities, INs generate spontaneous IPSCs (sIPSCs) that occur less frequently and exhibit smaller charge transfer, thus receiving less synaptic total current than PCs. Further distinction of PCs between intrinsically bursting (IB) and regular-spiking (RS) neuron

SUBMITTER: Panuccio G 

PROVIDER: S-EPMC3519474 | biostudies-literature | 2012

REPOSITORIES: biostudies-literature