Spatio-temporal expression pattern of frizzled receptors after contusive spinal cord injury in adult rats.

ABSTRACT:

Background

Wnt proteins are a large family of molecules that are critically involved in multiple central nervous system (CNS) developmental processes. Experimental evidences suggest a role for this family of proteins in many CNS disorders, including spinal cord injury (SCI), which is a major neuropathology owing to its high prevalence and chronic sensorimotor functional sequelae. Interestingly, most Wnt proteins and their inhibitors are expressed in the uninjured spinal cord, and their temporal expression patterns are dramatically altered after injury. However, little is known regarding the expression of their better-known receptors, the Frizzled family, after SCI. Thus, the aim of the present study was to evaluate the expression of Frizzled receptors in the damaged spinal cord.

SUBMITTER: Gonzalez P 

PROVIDER: S-EPMC3519492 | biostudies-literature | 2012

REPOSITORIES: biostudies-literature