Resveratrol prevents EBV transformation and inhibits the outgrowth of EBV-immortalized human B cells.

ABSTRACT:

Background

Epstein Barr virus-associated lymphoproliferative disease is an increasing complication in patients with immunosuppressive conditions. Although the current therapies for this disorder are effective, they are also associated with significant toxicity. In an attempt to identify newer therapeutic agents, this study investigated the effects of Resveratrol, a naturally occurring polyphenolic compound, on the EBV transformation of human B cells.

Methodology/principal findings

This study demonstrates that resveratrol prevents EBV transformation in human B cells. These effects are mediated by specific cytotoxic activities of resveratrol against EBV-infected B cells that are associated with the downregulation of the anti-apoptotic proteins Mcl-1 and survivin. This occurs a

SUBMITTER: Espinoza JL 

PROVIDER: S-EPMC3519585 | biostudies-literature | 2012

REPOSITORIES: biostudies-literature