Transmission dynamics of the four dengue serotypes in southern Vietnam and the potential impact of vaccination.

ABSTRACT:

Background

With approximately 2.5 billion people at risk, dengue is a major international public health concern. Dengue vaccines currently in development should help reduce the burden associated with this disease but the most efficient way of using future dengue vaccines remains to be defined. Mathematical models of transmission can provide insight into the expected impact of different vaccination strategies at a population level and contribute to this definition.

Methods and findings

We developed and analyzed an age-structured, host-vector and serotype-specific compartmental model, including seasonality. We first used this transmission model to identify the immunological interactions between serotypes that affect the risks and consequences of secondary infections (cross-pro

SUBMITTER: Coudeville L 

PROVIDER: S-EPMC3519629 | biostudies-literature | 2012

REPOSITORIES: biostudies-literature