Associations of BDNF genotype and promoter methylation with acute and long-term stroke outcomes in an East Asian cohort.

ABSTRACT:

Background

Brain derived neurotrophic factor (BDNF) has been shown to play an important role in poststroke recovery. BDNF secretion is influenced by genetic and epigenetic profiles. This study aimed to investigate whether BDNF val66met polymorphism and promoter methylation status were associated with outcomes at two weeks and one year after stroke.

Methods and findings

A total of 286 patients were evaluated at the time of admission and two weeks after stroke, and 222 (78%) were followed one year later in order to evaluate consequences of stroke at both acute and chronic stages. Stroke outcomes were dichotomised into good and poor by the modified Rankin Scale. Stroke severity (National Institutes of Health Stroke Scale), physical disability (Barthel Index), and cognitive func

SUBMITTER: Kim JM 

PROVIDER: S-EPMC3519835 | biostudies-literature | 2012

REPOSITORIES: biostudies-literature