Circulating branched-chain amino acid concentrations are associated with obesity and future insulin resistance in children and adolescents.

ABSTRACT:

Unlabelled

What is already known about this subject Circulating concentrations of branched-chain amino acids (BCAAs) can affect carbohydrate metabolism in skeletal muscle, and therefore may alter insulin sensitivity. BCAAs are elevated in adults with diet-induced obesity, and are associated with their future risk of type 2 diabetes even after accounting for baseline clinical risk factors. What this study adds Increased concentrations of BCAAs are already present in young obese children and their metabolomic profiles are consistent with increased BCAA catabolism. Elevations in BCAAs in children are positively associated with insulin resistance measured 18 months later, independent of their initial body mass index.

Background

Branched-chain amino acid (BCAA) concentrations are

SUBMITTER: McCormack SE 

PROVIDER: S-EPMC3519972 | biostudies-literature | 2013 Feb

REPOSITORIES: biostudies-literature