RabGDI controls axonal midline crossing by regulating Robo1 surface expression.

ABSTRACT:

Background

Axons navigate to their future synaptic targets with the help of choice points, intermediate targets that express axon guidance cues. Once they reach a choice point, axons need to switch their response from attraction to repulsion in order to move on with the next stage of their journey. The mechanisms underlying the change in axonal responsiveness are poorly understood. Commissural axons become sensitive to the repulsive activity of Slits when they cross the ventral midline of the CNS. Responsiveness to Slits depends on surface expression of Robo receptors. In Drosophila, Commissureless (Comm) plays a crucial regulatory role in midline crossing by keeping Robo levels low on precommissural axons. Interestingly, to date no vertebrate homolog of comm has been identified. R

SUBMITTER: Philipp M 

PROVIDER: S-EPMC3520763 | biostudies-literature | 2012 Nov

REPOSITORIES: biostudies-literature