Manipulating the mediator: modulation of the alternative complement pathway C3 convertase in health, disease and therapy.

ABSTRACT: The complement network is increasingly recognized as an important triage system that is able to differentiate between healthy host cells, microbial intruders, cellular debris and immune complexes, and tailor its actions accordingly. At the center of this triage mechanism is the alternative pathway C3 convertase (C3bBb), a potent enzymatic protein complex capable of rapidly converting the inert yet abundant component C3 into powerful effector fragments (C3a and C3b), thereby amplifying the initial response on unprotected surfaces and inducing a variety of effector functions. A fascinating molecular mechanism of convertase assembly and intrinsic regulation, as well as the interplay with a panel of cell surface-bound and soluble inhibitors are essential for directing complement attack to intr

SUBMITTER: Ricklin D 

PROVIDER: S-EPMC3521040 | biostudies-literature | 2012 Nov

REPOSITORIES: biostudies-literature