Convergence of genome-wide association and candidate gene studies for alcoholism.

ABSTRACT:

Background

Genome-wide association (GWA) studies have led to a paradigm shift in how researchers study the genetics underlying disease. Many GWA studies are now publicly available and can be used to examine whether or not previously proposed candidate genes are supported by GWA data. This approach is particularly important for the field of alcoholism because the contribution of many candidate genes remains controversial.

Methods

Using the Human Genome Epidemiology (HuGE) Navigator, we selected candidate genes for alcoholism that have been frequently examined in scientific articles in the past decade. Specific candidate loci as well as all the reported single nucleotide polymorphisms (SNPs) in candidate genes were examined in the Study of Addiction: Genetics and Environment (

SUBMITTER: Olfson E 

PROVIDER: S-EPMC3521088 | biostudies-literature | 2012 Dec

REPOSITORIES: biostudies-literature