Polymorphism of tumor necrosis factor alpha (TNF-alpha) gene promoter, circulating TNF-alpha level, and cardiovascular risk factor for ischemic stroke.

ABSTRACT:

Background

Tumor necrosis factor-α (TNF-α) is one of the most typical pro-inflammatory cytokines with both beneficial and destructive properties for the central nervous system. Increasing evidences have demonstrated the important role of TNF-α in the development of ischemic stroke, but studies examining the possible association with stroke or direct functional effects of polymorphisms in TNF-α have been contradictory.

Findings

In this study, a 2-kb length of the proximal promoter of the TNF-α was screened and four polymorphisms were investigated in the case-control study. Our data confirmed the association between -308G/A variant with stroke in 1,388 stroke patients and 1,027 controls and replicated in an independent population of 961 stroke patients and 821 controls (odds r

SUBMITTER: Cui G 

PROVIDER: S-EPMC3521196 | biostudies-literature | 2012 Oct

REPOSITORIES: biostudies-literature