ILOCi: a SNP interaction prioritization technique for detecting epistasis in genome-wide association studies.

ABSTRACT:

Background

Genome-wide association studies (GWAS) do not provide a full account of the heritability of genetic diseases since gene-gene interactions, also known as epistasis are not considered in single locus GWAS. To address this problem, a considerable number of methods have been developed for identifying disease-associated gene-gene interactions. However, these methods typically fail to identify interacting markers explaining more of the disease heritability over single locus GWAS, since many of the interactions significant for disease are obscured by uninformative marker interactions e.g., linkage disequilibrium (LD).

Results

In this study, we present a novel SNP interaction prioritization algorithm, named iLOCi (Interacting Loci). This algorithm accounts for marker depe

SUBMITTER: Piriyapongsa J 

PROVIDER: S-EPMC3521387 | biostudies-literature | 2012

REPOSITORIES: biostudies-literature