Ontology highlight
ABSTRACT:
SUBMITTER: Hoshi N
PROVIDER: S-EPMC3521499 | biostudies-literature | 2012
REPOSITORIES: biostudies-literature
Nature communications 20120101
Commensal bacterial sensing by Toll-like receptors is critical for maintaining intestinal homeostasis, but can lead to colitis in the absence of interleukin-10. Although Toll-like receptors are expressed in multiple cell types in the colon, the cell type(s) responsible for the development of colitis are currently unknown. Here we generated mice that are selectively deficient in MyD88 in various cellular compartments in an interleukin-10(-/-) setting. Although epithelial expression of MyD88 was d ...[more]