Type 2 Diabetes Genetics: Beyond GWAS.

ABSTRACT: The global epidemic of type 2 diabetes mellitus (T2D) is one of the most challenging problems of the 21(st) century leading cause of and the fifth death worldwide. Substantial evidence suggests that T2D is a multifactorial disease with a strong genetic component. Recent genome-wide association studies (GWAS) have successfully identified and replicated nearly 75 susceptibility loci associated with T2D and related metabolic traits, mostly in Europeans, and some in African, and South Asian populations. The GWAS serve as a starting point for future genetic and functional studies since the mechanisms of action by which these associated loci influence disease is still unclear and it is difficult to predict potential implication of these findings in clinical settings. Despite extensive replicatio

SUBMITTER: Sanghera DK 

PROVIDER: S-EPMC3521576 | biostudies-literature | 2012 Jun

REPOSITORIES: biostudies-literature