Heat and risk of myocardial infarction: hourly level case-crossover analysis of MINAP database.

ABSTRACT:

Objective

To quantify the association between exposure to higher temperatures and the risk of myocardial infarction at an hourly temporal resolution.

Design

Case-crossover study.

Setting

England and Wales Myocardial Ischaemia National Audit Project (MINAP) database.

Participants

24,861 hospital admissions for myocardial infarction occurring in 11 conurbations during the warmest months (June to August) of the years 2003-09.

Main outcome measure

Odds ratio of myocardial infarction for a 1 °C increase in temperature.

Results

Strong evidence was found for an effect of heat acting 1-6 hours after exposure to temperatures above an estimated threshold of 20 °C (95% confidence interval 16 °C to 25 °C). For each 1 °C increase in temperature above this thre

SUBMITTER: Bhaskaran K 

PROVIDER: S-EPMC3521646 | biostudies-literature | 2012 Dec

REPOSITORIES: biostudies-literature