Opposite effect of inflammation on subventricular zone versus hippocampal precursors in brain injury.

ABSTRACT:

Objective

Inflammation promotes epidermal wound healing but is considered detrimental to recovery from central nervous system injury. Sick infants have increased levels of cytokines in their cerebrospinal fluid that correlate with poor neurological outcome. In this study, we investigated the role of neuroinflammation and more specifically interleukin 6 (IL-6) in the amplification of subventricular zone (SVZ) and subgranular zone (SGZ) neural precursors after neonatal brain injury.

Methods

Neonatal hypoxia/ischemia (H/I) was induced in P6 rat pups, and IL-6 was quantified with or without indomethacin administration. Neural precursor responses were evaluated by neurosphere assays as well as by stereological analyses. Studies were performed to determine how IL-6 and leukemia-in

SUBMITTER: Covey MV 

PROVIDER: S-EPMC3522429 | biostudies-literature | 2011 Oct

REPOSITORIES: biostudies-literature