Changes in the expression of aromatase, estrogen receptor α and β in mandibular condylar cartilage of rats induced by disordered occlusion.

ABSTRACT:

Background

Estrogens play an important role in modulating the morphology and function of temporomandibular joints (TMJs), which is suggested to act via estrogen receptors (ERs). The present study was to investigate the expression of aggrecan, collagen type II (Col II), Col X, aromatase, ERα and ERβ in degenerative changes of mandibular condylar cartilage.

Methods

Forty male and 40 female 8-week-old rats were enrolled in this study. In experimental groups, the disordered occlusion was created by moving the first molars mesially and the third ones distally. Immunohistochemistry and real-time PCR were performed at the end of the second or fourth week.

Results

Degenerative changes, characterized by interrupted continuity of hypertrophic layer, pyknotic and eosinophilic le

SUBMITTER: Yu S 

PROVIDER: S-EPMC3522542 | biostudies-literature | 2012 Sep

REPOSITORIES: biostudies-literature