Salvinorin A reduces mechanical allodynia and spinal neuronal hyperexcitability induced by peripheral formalin injection.

ABSTRACT:

Background

Salvinorin A (SA), the main active component of Salvia Divinorum, is a non-nitrogenous kappa opioid receptor (KOR) agonist. It has been shown to reduce acute pain and to exert potent antinflammatory effects. This study assesses the effects and the mode of action of SA on formalin-induced persistent pain in mice. Specifically, the SA effects on long-term behavioural dysfuctions and changes in neuronal activity occurring at spinal level, after single peripheral formalin injection, have been investigated. Moreover, the involvement of microglial and glial cells in formalin-induced chronic pain condition and in SA-mediated effects has been evaluated.

Results

Formalin induced a significant decrease of mechanical withdrawal threshold at the injected and contralateral paw

SUBMITTER: Guida F 

PROVIDER: S-EPMC3522567 | biostudies-literature | 2012 Aug

REPOSITORIES: biostudies-literature