Cutoff Finder: a comprehensive and straightforward Web application enabling rapid biomarker cutoff optimization.

ABSTRACT: Gene or protein expression data are usually represented by metric or at least ordinal variables. In order to translate a continuous variable into a clinical decision, it is necessary to determine a cutoff point and to stratify patients into two groups each requiring a different kind of treatment. Currently, there is no standard method or standard software for biomarker cutoff determination. Therefore, we developed Cutoff Finder, a bundle of optimization and visualization methods for cutoff determination that is accessible online. While one of the methods for cutoff optimization is based solely on the distribution of the marker under investigation, other methods optimize the correlation of the dichotomization with respect to an outcome or survival variable. We illustrate the functionality o

SUBMITTER: Budczies J 

PROVIDER: S-EPMC3522617 | biostudies-literature | 2012

REPOSITORIES: biostudies-literature